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      Rabbit Anti-Fibrinogen alpha chain/FITC Conjugated antibody (bs-7548R-FITC)
      訂購熱線:400-901-9800
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      說 明 書: 100ul  
      100ul/2980.00元
      大包裝/詢價
      產品編號 bs-7548R-FITC
      英文名稱 Anti-Fibrinogen alpha chain/FITC
      中文名稱 FITC標記的纖維蛋白原A鏈抗體
      別    名 FGA; Fib2; FIBA_HUMAN; Fibrinogen alpha chain; fibrinogen alpha chain isoform alpha preproprotein; Fibrinogen alpha/alpha E chain [Precursor]; fibrinogen alpha chain isoform alpha-E preproprotein; fibrinogen alpha chain isoform alpha preproprotein.  
      Journal
      PMID
      IF
      Application
      [IF=25.841] Eszter á. Tóth. et al. Formation of a protein corona on the surface of extracellular vesicles in blood plasma. J Extracell Vesicles. 2021 Sep;10(11):e12140  Other ;  Human.  
      規格價格 100ul/2980元 購買        大包裝/詢價
      說 明 書 100ul  
      研究領域 心血管  
      抗體來源 Rabbit
      克隆類型 Polyclonal
      交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, )
      產品應用 IF=1:50-200 
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      分 子 量 91kDa
      性    狀 Lyophilized or Liquid
      濃    度 1mg/ml
      免 疫 原 KLH conjugated synthetic peptide derived from human Fibrinogen alpha chain (80-125aa)
      亞    型 IgG
      純化方法 affinity purified by Protein A
      儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
      產品介紹 background:
      The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq, Jul 2008]

      Function:
      Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

      Subunit:
      Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.

      Subcellular Location:
      Secreted.

      Tissue Specificity:
      Plasma.

      Post-translational modifications:
      The alpha chain is not glycosylated.
      Forms F13A-mediated cross-links between a glutamine and the epsilon-amino group of a lysine residue, forming fibronectin-fibrinogen heteropolymers.
      About one-third of the alpha chains in the molecules in blood were found to be phosphorylated.
      Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
      Phosphorylation sites are present in the extracellular medium.

      DISEASE:
      Defects in FGA are a cause of congenital afibrinogenemia (CAFBN) [MIM:202400]. This is a rare autosomal recessive disorder characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Note=The majority of cases of afibrinogenemia are due to truncating mutations. Variations in position Arg-35 (the site of cleavage of fibrinopeptide a by thrombin) leads to alpha-dysfibrinogenemias.
      Defects in FGA are a cause of amyloidosis type 8 (AMYL8) [MIM:105200]; also known as systemic non-neuropathic amyloidosis or Ostertag-type amyloidosis. AMYL8 is a hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.

      Similarity:
      Contains 1 fibrinogen C-terminal domain.

      Database links:
      Entrez Gene: 2243 Human

      Entrez Gene: 14161 Mouse

      Omim: 134820 Human

      SwissProt: P02671 Human

      SwissProt: Q99K47 Mouse

      Unigene: 351593 Human

      Unigene: 88793 Mouse



      Important Note:
      This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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