• <var id="qfbm7"><legend id="qfbm7"></legend></var>
    <th id="qfbm7"><track id="qfbm7"></track></th>

      <dd id="qfbm7"></dd>

      <rp id="qfbm7"></rp>

      <em id="qfbm7"></em>
      掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
      客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  人才招聘  關于我們  聯系我們
      產品中心-北京博奧森生物技術有限公司
      首頁 > 產品中心 > 一抗 > 產品信息
      Mouse Anti-S100A8 antibody (bsm-33861M)
      ~~~促銷,代碼SSY221101~~~
      訂購熱線:400-901-9800
      訂購郵箱:sales@bioss.com.cn
      訂購QQ:  400-901-9800
      技術支持:techsupport@bioss.com.cn
      說明書: 50ul  100ul  
      50ul/1138.00元
      100ul/1880.00元
      大包裝/詢價

      產品編號 bsm-33861M
      英文名稱 S100A8
      中文名稱 S100鈣結合蛋白A8單克隆抗體
      別    名 60B8Ag; AI323541; B8Ag; BEE11; CAGA; Calgranulin-A; Calprotectin L1L subunit; Calprotectin, included; CFAG; CGLA; Chemotactic cytokine CP-10; CP-10; Cystic fibrosis antigen; L1Ag; Leukocyte L1 complex light chain; MA387; MIF; Migration inhibitory factor-related protein 8; MRP-8; Myeloid-related protein 8; Neutrophil cytosolic 7 kDa protein; NIF; p8; Pro-inflammatory S100 cytokine; Protein S100-A8; S100 calcium binding protein A8 (calgranulin A); S100 calcium binding protein A8; S100 calcium-binding protein A8; S100A8; S100A8/S100A9 complex, included; S10A8_MOUSE; Urinary stone protein band A.  
      研究領域 腫瘤  神經生物學  
      抗體來源 Mouse
      克隆類型 Monoclonal
      克 隆 號 9B10
      交叉反應 Human, 
      產品應用 IHC-P=1:200-500 (石蠟切片需做抗原修復)
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      理論分子量 10kDa
      細胞定位 細胞漿 細胞膜 分泌型蛋白 
      性    狀 Lyophilized or Liquid
      濃    度 1mg/ml
      免 疫 原 Recombinant human S100A8 protein 
      亞    型 IgG1
      純化方法 affinity purified by Protein A
      緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
      PubMed PubMed
      產品介紹 The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. [provided by RefSeq].

      Function:
      S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants.

      Subunit:
      Homodimer. Heterotetramer with S100A9.

      Subcellular Location:
      Secreted. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein.

      Tissue Specificity:
      Expressed by macrophages in chronic inflammations. Also expressed in epithelial cells constitutively or induced during dermatoses.

      Similarity:
      Belongs to the S-100 family.
      Contains 2 EF-hand domains.

      SWISS:
      P05109

      Gene ID:
      6279

      Database links:

      Entrez Gene: 6279 Human

      Entrez Gene: 20201 Mouse

      Omim: 123885 Human

      SwissProt: P05109 Human

      SwissProt: P27005 Mouse

      Unigene: 416073 Human

      Unigene: 21567 Mouse



      產品圖片
      Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (S100A8) Monoclonal Antibody, Unconjugated (bsm-33861M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
      Paraformaldehyde-fixed, paraffin embedded (human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (S100A8) Monoclonal Antibody, Unconjugated (bsm-33861M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
      Paraformaldehyde-fixed, paraffin embedded (human lung carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (S100A8) Monoclonal Antibody, Unconjugated (bsm-33861M) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Mouse)(sp-0024) instructionsand DAB staining.
      版權所有 2019-2022 www.sznuigl.com 北京博奧森生物技術有限公司
      通過國際質量管理體系ISO9001:2008 GB/T19001-2008認證    編號:00115Q211807R1M/1100
      京ICP備05066980號-1         京公網安備110107000727號
      97国产在线高清不卡视频,成 人 黄 色 网 站 视频,国产丰满老熟女重口对白,国模gogo中国人体私拍