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      Mouse Anti-PIK3R1 (animal-free) antibody (bsm-77002M)
      ~~~促銷,代碼SSY221101~~~
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      產品編號 bsm-77002M
      英文名稱 PIK3R1 (animal-free)
      中文名稱 磷脂酰肌醇激酶單克隆抗體 (無動物源)
      別    名 P85A_HUMAN; Phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha (PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha); PI 3-kinase p85α; PI 3-kinase p85 α; PI 3-kinase p85-α; SH3_PI3K_p85alpha; PI3-kinase p85 subunit alpha; phosphoinositide-3-kinase regulatory subunit 1; p85; AGM7; IMD36; p85-ALPHA; PI 3 Kinase p85 alpha;   
      Specific References  (1)     |     bsm-77002M has been referenced in 1 publications.
      [IF=3.24] Jing Hu. et al. Investigation of the active ingredients and pharmacological mechanisms of Porana sinensis Hemsl. Against rheumatoid arthritis using network pharmacology and experimental validation. Plos One. 2022 Mar;17(3):e0264786  WB ;  Rat.  
      研究領域 腫瘤  細胞生物  免疫學  信號轉導  激酶和磷酸酶  
      抗體來源 Mouse
      克隆類型 Monoclonal
      克 隆 號 5C11
      交叉反應 Human, Mouse, Rat, 
      產品應用 WB=1:500-2000 
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      理論分子量 80kDa
      細胞定位 細胞核 細胞漿 細胞膜 
      性    狀 Liquid
      濃    度 1mg/ml
      免 疫 原 Recombinant mouse PI3K p85 Protein: 1-110/724 
      亞    型 IgG
      純化方法 affinity purified by Protein A
      緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
      PubMed PubMed
      產品介紹 The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

      Function:
      Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.

      Subunit:
      Heterodimer of a regulatory subunit PIK3R1 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with FER. Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated). Interacts with PTK2/FAK1 (By similarity). Interacts with phosphorylated TOM1L1. Interacts with phosphorylated LIME1 upon TCR and/or BCR activation. Interacts with SOCS7. Interacts with RUFY3. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated). Interacts with LYN (via SH3 domain); this enhances enzyme activity. Interacts with phosphorylated LAT, LAX1 and TRAT1 upon TCR activation. Interacts with CBLB. Interacts with HIV-1 Nef to activate the Nef associated p21-activated kinase (PAK). This interaction depends on the C-terminus of both proteins and leads to increased production of HIV. Interacts with HCV NS5A. The SH2 domains interact with the YTHM motif of phosphorylated INSR in vitro. Also interacts with tyrosine-phosphorylated IGF1R in vitro. Interacts with CD28 and CD3Z upon T-cell activation. Interacts with IRS1 and phosphorylated IRS4, as well as with NISCH and HCST. Interacts with FASLG, KIT and BCR. Interacts with AXL, FGFR1, FGFR2, FGFR3 and FGFR4 (phosphorylated). Interacts with FGR and HCK. Interacts with PDGFRA (tyrosine phosphorylated) and PDGFRB (tyrosine phosphorylated). Interacts with ERBB4 (phosphorylated). Interacts with NTRK1 (phosphorylated upon ligand-binding).

      Tissue Specificity:
      Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).

      Post-translational modifications:
      Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
      Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR.

      Similarity:
      Belongs to the PI3K p85 subunit family.
      Contains 1 Rho-GAP domain.
      Contains 2 SH2 domains.

      SWISS:
      P27986

      Gene ID:
      18708

      Database links:

      Entrez Gene: 5295 Human

      Entrez Gene: 18708 Mouse

      Entrez Gene: 25513 Rat

      Omim: 171833 Human

      SwissProt: P27986 Human

      SwissProt: P26450 Mouse

      SwissProt: Q63787 Rat

      Unigene: 132225 Human



      產品圖片
      Sample:
      Lane 1: Mouse Cerebrum tissue lysates
      Lane 2: Mouse Heart tissue lysates
      Lane 3: Mouse Spleen tissue lysates
      Lane 4: Rat Cerebrum tissue lysates
      Lane 5: Rat Muscle tissue lysates
      Lane 6: Rat Heart tissue lysates
      Lane 7: Rat Spleen tissue lysates
      Lane 8: Human Jurkat cell lysates
      Lane 9: Human K562 cell lysates
      Lane 10: Human Molt-4 cell lysates
      Lane 11: Human HL60 cell lysates
      Primary: Anti-PI 3 Kinase p85 alpha (bsm-77002M) at 1/1000 dilution
      Secondary: IRDye800CW Goat Anti-Mouse IgG at 1/20000 dilution
      Predicted band size: 80 kD
      Observed band size: 80 kD
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