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      RabbitAnti-C-Myc antibody (bs-4963R)
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      產品編號 bs-4963R
      英文名稱 C-Myc
      中文名稱 致癌基因C-Myc抗體
      別    名 AU016757; Avian myelocytomatosis viral oncogene homolog; bHLHe39; Cellular myelocytomatosis oncogene; MGC105490; MRTL; Myc protein; Myc proto oncogene protein; Myc-related translation/localization regulatory factor; Myc2; myca; Myelocytomatosis oncogene a; Myelocytomatosis oncogene; Niard; Nird; Oncogene Myc; Protooncogene homologous to myelocytomatosis virus; RNCMYC; Transcription factor p64; Transcriptional regulator Myc-A; v myc avian myelocytomatosis viral oncogene homolog; v myc myelocytomatosis viral oncogene homolog (avian); V-Myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog (avian); zc-myc; MYC_HUMAN.  
      Specific References  (19)     |     bs-4963R has been referenced in 19 publications.
      [IF=2.146] Yang Lv. et al. TGF-β1 enhanced myocardial differentiation through inhibition of the Wnt/β-catenin pathway with rat BMSCs. Iran J Basic Med Sci. 2020 Aug; 23(8): 1012–1019  WB ;  Rat.  
      [IF=5.31] Meiju Zhang. et al. The role of E2A in ATPR-induced cell differentiation and cycle arrest in acute myeloid leukaemia cells. J Cell Mol Med. 2022 Feb;26(4):1128-1143  IF,IHC ;  Human,Mouse.  
      [IF=5.201] Min Pengxiang. et al. MICAL-L2 Is Essential for c-Myc Deubiquitination and Stability in Non-small Cell Lung Cancer Cells. Front Cell Dev Biol. 2021 Jan;8:1798  IHC ;  Human.  
      [IF=4.486] Chen Y et al. PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β‐catenin signalling pathway. J Cell Mol Med . 2020 Jul;24(13):7405-7416.  WB ;  Mouse&Human.  
      [IF=2.146] Lv Y et al. TGF-β1 enhanced myocardial differentiation through inhibition of the Wnt/β-catenin pathway with rat BMSCs. Iran J Basic Med Sci . 2020 Aug;23(8):1012-1019.  WB ;  Rat.  
      [IF=4.486] Chen Y et al. PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/β‐catenin signalling pathway. J Cell Mol Med. 2020 Jul;24(13):7405-7416.  WB ;  Mouse.  
      [IF=4.963] Shi et al. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately. (2015) Stem.Cell.Res.Ther. 6:120  WB ;  Human,?Mouse,?Rat,?Dog,?Pig,?Cow,?Rabbit,?Sheep,.  
      [IF=2.51] Gao, Qian, et al. "Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs." Molecular biology reports 39.5 (2012): 5791-5804.  Rat.  
      [IF=4.679] Gong Y et al. Smad3 C-terminal phosphorylation site mutation attenuates the hepatoprotective effect of salvianolic acid B against hepatocarcinogenesisFood Chem Toxicol.2021 Jan;147:111912.  WB、IF ;  Mouse.  
      [IF=25.671] Shi, Ningning. et al. Restoration of dystrophin expression in mice by suppressing a nonsense mutation through the incorporation of unnatural amino acids. Nat Biomed Eng. 2021 Aug;:1-12  WB ;  Human.  
      [IF=18.952] Mahmoud Labibet al. Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting. Nat Biomed Eng . 2020 Jul 27.  FCM ;  Human.  
      [IF=3.17] Yang J et al. MicroRNA-708 represses hepatic stellate cells activation and proliferation by targeting ZEB1 through Wnt/β-catenin pathway. Eur J Pharmacol. 2020 Mar 15;871:172927.  WB ;  Mouse&Human.  
      [IF=2.776] Niu K et al. Pepsin promotes laryngopharyngeal neoplasia by modulating signaling pathways to induce cell proliferation. PLoS One. 2020 Jan 15;15(1):e0227408.  ICF ;  Human.  
      [IF=2.152] Zhao B et al. Characterization of HTATIP2 and its role during hair follicle cycles in Angora rabbit. Genome. 2020 Jan 9:1-9.  WB ;  Rabbit.  
      [IF=6.044] Li Y et al. Apple polysaccharide protects ICR mice against colitis associated colorectal cancer through the regulation of microbial dysbiosis. Carbohydr Polym. 2020 Feb 15;230:115726.  WB ;  Mouse&Human.  
      [IF=3.547] Li B et al. Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases. Toxicology. 2019 Nov 3;429:152312.  WB ;  Rat.  
      [IF=3.571] Wang J et al. Influence of calcium supplementation against fluoride-mediated osteoblasts impairment in vitro: Involvement of canonical Wnt/β-catenin signaling pathway. J Agric Food Chem. 2019 Sep 4.  WB ;  Mouse.  
      [IF=3.04] Ma W et al. A vanillin derivative suppresses the growth of HT29 cells through the Wnt/β-catenin signaling pathway. Eur J Pharmacol. 2019 Apr 15;849:43-49.  WB ;  Human.  
      [IF=2.58] Jiang, Xiao-Hua, et al. "Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway." BMC microbiology 17.1 (2017): 124.  WB ;  Human.  
      研究領域 腫瘤  細胞生物  信號轉導  干細胞  生長因子和激素  轉錄調節因子  激酶和磷酸酶  表觀遺傳學  
      抗體來源 Rabbit
      克隆類型 Polyclonal
      交叉反應 Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, )
      產品應用 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100 IF=1:100-500 (石蠟切片需做抗原修復)
      not yet tested in other applications.
      optimal dilutions/concentrations should be determined by the end user.
      理論分子量 49kDa
      細胞定位 細胞核 
      性    狀 Liquid
      濃    度 1mg/ml
      免 疫 原 KLH conjugated synthetic peptide derived from human C-Myc: 101-200/439 
      亞    型 IgG
      純化方法 affinity purified by Protein A
      緩 沖 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
      保存條件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
      注意事項 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
      PubMed PubMed
      產品介紹 The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008].

      Function:
      Participates in the regulation of gene transcription. Binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.

      Subunit:
      Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66.

      Subcellular Location:
      Nucleus, nucleoplasm. Nucleus, nucleolus.

      Post-translational modifications:
      Phosphorylated by PRKDC. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
      Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex.

      DISEASE:
      Note=Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.
      Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.
      Defects in MYC are a cause of Burkitt lymphoma (BL) [MIM:113970]. A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. Note=Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.

      Similarity:
      Contains 1 basic helix-loop-helix (bHLH) domain.

      SWISS:
      P01106

      Gene ID:
      4609

      Database links:

      Entrez Gene: 4609 Human

      Entrez Gene: 17869 Mouse

      Entrez Gene: 24577 Rat

      Omim: 190080 Human

      SwissProt: P01106 Human

      SwissProt: P01108 Mouse

      SwissProt: P09416 Rat

      Unigene: 202453 Human

      Unigene: 2444 Mouse

      Unigene: 12072 Rat



      產品圖片
      Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded;
      Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
      Incubation: Anti-C-Myc Polyclonal Antibody, Unconjugated(bs-4963R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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